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How It Works (The Science): Tesofensine increases the levels of three key neurotransmitters in the brainserotonin, norepinephrine, and dopamineby blocking their presynaptic reuptake

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The ALS-linked E102Q mutation in Sigma receptor-1 leads to ER stress-mediated defects in protein homeostasis and dysregulation of RNA-binding proteins

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Their benefits extend across the ejection fraction spectrum and are observed irrespective of diabetes status [8, 10, 11, 46]